webinar recording: resolving the question of on- or off-target toxicity – a case study
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webinar recording: resolving the question of on- or off-target toxicity – a case study
The question of whether toxicity caused by small molecules is due to on-target or off-target pharmacological effects is frequently encountered in drug discovery programs and of decision making significance. Genetically engineered mouse models are widely used to assess the safety consequences of depleting a target, but have limitations in ...
681 viewsMay 19, 2017
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