Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Fifteen years ago, physicists worked out a method to increase image contrast by hitting the electron imaging beam with an ...

Light-sheet fluorescence microscopy (LSFM) has allowed for faster three-dimensional imaging of biological samples with lower photo-bleaching and photo-toxicity than confocal microscopy 1. This is ...

Hosts of new applications have turned the light microscope into an exquisitely sensitive measuring device that can be used to image dynamic cellular events right down to the molecular level. Indeed, ...

Fluorescence microscopy offers unparalleled access to the spatial organization and dynamics of biological events in living samples, yet capturing rare processes over extended durations remains ...