How to reduce animal numbers and increase the information content of animal-based studies. A ‘well-built’ research question turns the research hypothesis into an actionable, focused, and testable plan ...

Designing good research questions goes well beyond the standard definitions of clarity, focus and tractability, and even beyond ‘novelty’ in the strictest sense. This Comment describes the iterative ...

As a researcher who has used a wide variety of methodologies, I understand the importance of acknowledging that we, as researchers, do not pick the methodology; rather, the research question dictates ...