Scientists have identified a conserved aging-related protein, EPS8, that promotes toxic protein aggregation linked to neurodegenerative diseases.

An Oregon State University scientist and a team of undergraduate students have uncovered real-time insights into a chemical process linked with Alzheimer's disease, paving the way toward better drug ...

Neurodegenerative diseases, such as Alzheimer's disease and dementia, are medical conditions that entail the progressive loss of neurons and a decline in brain function. Past studies have found a link ...

Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

Proteins often function in pairs or groups, concealing their internal connection points and making it difficult for ...

Purdue University researchers have taken the first steps to treat Alzheimer’s disease, Parkinson’s disease and Type 2 diabetes by creating multiple patent-pending compounds shown to inhibit protein ...

Clearance mechanisms are key to removing aggregates and maintaining metastability.

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region ...

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington’s, Alzheimer’s and Parkinson’s. But to the human eye, proteins that are ...