In the ongoing effort to determine just how much of who we are is preordained by our genetic code, heritability, a statistical measurement of how much variation in a trait can be attributed to genetic ...

The COVID-19 pandemic gave us tremendous perspective on how wildly symptoms and outcomes can vary between patients ...

AlphaGenome is a DNA sequence model that advances regulatory variant-effect prediction to understand genome function.

Using single-cell epigenomic profiling of immune cells from 110 individuals, researchers show that genetic variation and ...

The human genome is organised in 46 chromosomes, where all but the x and y chromosomes in men are present in two copies. This means that a person with a faulty gene on one chromosome most often has a ...

The past decade has delivered landmark advances in human and medical genomics that shape how we understand disease mechanisms ...

Knowing how human DNA changes over generations is essential to estimating genetic disease risks and understanding how we evolved. But some of the most changeable regions of our DNA have been ...

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head impacts (RHI). However, individuals with similar RHI exposure have shown differing pathology, suggesting ...

Genetic variation in livestock is a critical area of research that underpins modern breeding practices and agricultural productivity. Differences in DNA sequences, including single nucleotide ...

Research into genetic variation and wool traits in sheep and goats has revealed critical insights into the structural composition and quality of animal fibres. Studies have focused on ...

By integrating long-read and short-read transcriptomics with whole-genome resequencing, the team uncovered specific transcript variants and genetic ...

A research team reveals that alternative splicing (AS), a key post-transcriptional gene regulation mechanism, plays an ...