If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal metabolic processes or external stressors such as radiation or chemical ...

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress. The findings of the UC ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most powerful genetic "on switches" in cancer cells, called super-enhancers, drive ...

A research team from the University of California (UC), Irvine, has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. The ...

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Objectives Understanding the molecular changes in the preclinical synovium is crucial for identifying factors that drive ...

Irvine, Calif., Dec. 3, 2024 – A research team co-led by the University of California, Irvine has discovered that accumulated DNA damage in the retina is a key contributor to age-related macular ...