The latest short science news items from C&EN. Open an introductory chemistry textbook. What is a covalent bond? A covalent bond occurs when atoms share electrons in a molecule. What is a hydrogen ...

One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent bonds with their ...

Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these advantages, protein-reactive compounds are ...

When most small-molecule drugs meet a protein target, they nestle close to their intended. But the flirtatious relationship between drug and target is often fleeting, with the drug repeatedly drifting ...